Which protein is responsible for actively transporting the active metabolite PQ+ into dopamine neurons?
Answer
Dopamine Transporter (DAT)
The dopamine neurons, which are selectively vulnerable to paraquat, express the dopamine transporter (DAT) on their membranes. Under normal conditions, this protein is responsible for the reuptake of dopamine from the synaptic cleft. The active toxin PQ+ mimics dopamine and acts as a substrate for DAT, allowing it to be pulled inside the neuron. Once inside, the accumulation of this substance disrupts cellular processes, leading to neuronal death.
Related Questions
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