Exposure to paraquat is associated with the aggregation of which hallmark protein found in Parkinson's disease?
Answer
Alpha-synuclein
Beyond the immediate destruction caused by oxidative stress, chronic or repeated exposure to paraquat triggers complex cellular pathology. One of these effects is the up-regulation and abnormal aggregation of alpha-synuclein. This protein is a central feature of the neuropathology associated with Parkinson's disease, and its accumulation contributes to the progressive nature of the condition, mirroring the changes observed in human patients.
Related Questions
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