Why is post-reversal observation critical, given naloxone's duration of effect (30 to 90 minutes)?
Answer
Because some illicit opioids can remain active in the body longer than the naloxone lasts.
Naloxone is a short-acting medication, with its effects typically lasting between 30 to 90 minutes. Many illicitly obtained opioids, however, can remain active in the person's system for a significantly longer duration. This discrepancy means that once the naloxone wears off, the opioids can re-bind to the receptors, leading to a relapse of respiratory depression. Therefore, even after a successful reversal, continuous observation and transport to a medical facility are vital until EMS takes over.
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