How does naloxone chemically interact with opioid receptors during an overdose?
Answer
It acts as a competitive blocker, kicking the opioid molecules off the receptors.
The mechanism of action for naloxone relies on competitive antagonism at the opioid receptors. Opioids slow or stop breathing by occupying these critical receptors. Naloxone possesses a chemical structure that allows it to fit into these same receptor sites. Upon administration, naloxone rapidly displaces the opioid molecules, effectively 'kicking them off' the receptors. This displacement immediately allows the person’s natural respiratory system to begin functioning again, restoring breathing.
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