Which substances' overdoses will naloxone administration have no effect upon?
Answer
Alcohol, benzodiazepines, or stimulants
Naloxone is exclusively an opioid reversal agent. Its specificity means it is entirely ineffective against overdoses caused by substances that are not opioids, such as central nervous system depressants like alcohol or benzodiazepines (e.g., Xanax or Valium), or stimulants like methamphetamine. In cases where these substances are involved, naloxone will not reverse the underlying cause of unresponsiveness.
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