What is the primary, temporary side effect experienced when naloxone reverses opioid binding?
Answer
Precipitated withdrawal symptoms like nausea and agitation
The main adverse effect associated with the successful reversal by naloxone is the abrupt onset of precipitated withdrawal. This occurs because the administered naloxone suddenly knocks the active opioids off their receptors, instantly causing the body to experience the full force of opioid withdrawal. Symptoms associated with this state are temporary but severe, typically including nausea, vomiting, anxiety, agitation, muscle aches, and a rapid heart rate. While these effects are uncomfortable, they are medically preferable to death from respiratory arrest.
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