What does a negative MRD result actually state regarding the residual cancer load?

Answer

The residual cancer load is below that specific test's quantifiable threshold

A result stating that Minimal Residual Disease (MRD) is negative is critically dependent on the technical capabilities of the assay used for testing. This result confirms that the quantity of residual cancer cells present in the sample is below the specific test's limit of detection—the quantifiable threshold at which that particular test can reliably measure or visualize the disease. This is a crucial distinction because it represents a statement regarding current testing capability rather than providing an absolute, biological certainty that zero cancer cells exist anywhere in the body. A negative result is highly favorable but is relative to the precision of the molecular diagnostic tool employed.

What does a negative MRD result actually state regarding the residual cancer load?

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