Why do new or changing pigmented lesions on the palms or soles sometimes warrant prompt evaluation?
Answer
Certain skin cancers have a higher incidence in these areas
Extra vigilance is advised for new or changing pigmented marks found specifically on the palms of the hands or the soles of the feet because these locations are known predilection sites for specific, aggressive forms of skin cancer, such as acral lentiginous melanoma. While these areas receive less direct sunlight than regions like the face or arms, the potential presence of these lesions necessitates prompt medical review to ensure early detection. If a mark is found under the fingernail or toe nail, darkening the nail bed, this specific location also heightens the need for a swift physician assessment, regardless of recent injury history.

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