What is a significant long-term risk of high-dose zinc supplementation?
Answer
It can impair the absorption of copper and lead to a deficiency
Zinc and copper are locked in an absorption struggle within the body. Consuming zinc above the tolerable upper intake level of 40 mg per day for extended periods interferes with the body's ability to absorb copper. This disruption can eventually manifest as negative health consequences, such as anemia or muscle weakness, which are direct results of the secondary copper deficiency caused by the long-term zinc imbalance.

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