What component of the venom is thermally denatured during hot water immersion to reduce lingering pain from a Man-o'-War sting?

Answer

Protein-based venom.

The lingering, agonizing pain associated with a Man-o'-War sting is largely attributed to the complex chemistry of the venom injected into the tissues. This venom is primarily composed of proteins. The application of high heat via hot water immersion acts as a chemical denaturing agent. Denaturation occurs when heat disrupts the tertiary structure of the proteins, rendering them biologically inactive. By breaking down these venom proteins, the thermal treatment effectively neutralizes their toxic effect, leading to significant and sustained pain relief, which is why this step is prioritized after initial decontamination.

What component of the venom is thermally denatured during hot water immersion to reduce lingering pain from a Man-o'-War sting?
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