Which receptor complex does Diazepam bind to, enhancing the effects of the primary inhibitory neurotransmitter?
Answer
GABA-A receptor complex
Diazepam functions by enhancing the activity of gamma-aminobutyric acid (GABA), which is identified as the brain's primary inhibitory neurotransmitter. Specifically, diazepam binds to allosteric sites on the GABA-A receptor complex. This binding action increases the frequency with which the associated chloride channels open. The resulting influx of chloride ions leads to hyperpolarization of the neuron, ultimately causing overall central nervous system (CNS) depression. This mechanism is distinct from baclofen’s action and is responsible for diazepam's broad effects, including its anxiolytic, anticonvulsant, and sedative properties.
Related Questions
Which receptor complex does Diazepam bind to, enhancing the effects of the primary inhibitory neurotransmitter?What is the fundamental difference in receptor classification between Baclofen and Diazepam?What is the predominant medical indication for Baclofen, contrasting with Diazepam's primary uses?Which formulation route is available for Baclofen therapy, specifically for severe, unresponsive spasticity?What physiological outcome results from Diazepam binding to the GABA-A receptor complex?Which specific side effect profile is generally more pronounced due to Diazepam's action via the GABA-A enhancement?When discontinuing long-term Baclofen therapy abruptly, what severe reaction, distinct from standard benzodiazepine withdrawal, can occur?Which organ system is primarily responsible for clearing Baclofen from the body, necessitating caution in related impairment?For what acute medical events is the rapid onset of Diazepam often prioritized over Baclofen's slower oral action?How does Baclofen primarily act on motor neurons to reduce spasticity at its main site of action?