What physiological outcome results from Diazepam binding to the GABA-A receptor complex?

Answer

Increased frequency of chloride channel opening leading to neuronal hyperpolarization.

When diazepam binds to its target, the GABA-A receptor complex, it functions to potentiate the effects of GABA. This potentiation manifests as a direct physical change in the receptor structure, causing an increase in how frequently the associated chloride channels open. When these channels open, negatively charged chloride ions flow into the neuron. This influx shifts the neuron's electrical potential towards a more negative state, a process known as hyperpolarization. This state makes the neuron less likely to fire an action potential, resulting in generalized central nervous system depression, which underlies diazepam's sedative and muscle-relaxing effects.

What physiological outcome results from Diazepam binding to the GABA-A receptor complex?

Related Questions

Which receptor complex does Diazepam bind to, enhancing the effects of the primary inhibitory neurotransmitter?What is the fundamental difference in receptor classification between Baclofen and Diazepam?What is the predominant medical indication for Baclofen, contrasting with Diazepam's primary uses?Which formulation route is available for Baclofen therapy, specifically for severe, unresponsive spasticity?What physiological outcome results from Diazepam binding to the GABA-A receptor complex?Which specific side effect profile is generally more pronounced due to Diazepam's action via the GABA-A enhancement?When discontinuing long-term Baclofen therapy abruptly, what severe reaction, distinct from standard benzodiazepine withdrawal, can occur?Which organ system is primarily responsible for clearing Baclofen from the body, necessitating caution in related impairment?For what acute medical events is the rapid onset of Diazepam often prioritized over Baclofen's slower oral action?How does Baclofen primarily act on motor neurons to reduce spasticity at its main site of action?
medicationtreatmentdrugpharmacologyComparison