How does Baclofen primarily act on motor neurons to reduce spasticity at its main site of action?

Answer

By inhibiting the release of excitatory neurotransmitters from presynaptic terminals.

Baclofen exerts its therapeutic effect against spasticity by targeting GABA-B receptors, which are predominantly located on the presynaptic terminals within the spinal cord. When Baclofen activates these receptors, the resulting signaling cascade acts to inhibit the further release of excitatory neurotransmitters. By reducing the signaling input from the presynaptic side, Baclofen effectively dampens the excitability of the motor neurons responsible for causing the pathological muscle stiffness (spasticity). This targeted presynaptic inhibition is what differentiates its mechanism from the generalized CNS depression caused by GABA-A modulators like diazepam.

How does Baclofen primarily act on motor neurons to reduce spasticity at its main site of action?

Related Questions

Which receptor complex does Diazepam bind to, enhancing the effects of the primary inhibitory neurotransmitter?What is the fundamental difference in receptor classification between Baclofen and Diazepam?What is the predominant medical indication for Baclofen, contrasting with Diazepam's primary uses?Which formulation route is available for Baclofen therapy, specifically for severe, unresponsive spasticity?What physiological outcome results from Diazepam binding to the GABA-A receptor complex?Which specific side effect profile is generally more pronounced due to Diazepam's action via the GABA-A enhancement?When discontinuing long-term Baclofen therapy abruptly, what severe reaction, distinct from standard benzodiazepine withdrawal, can occur?Which organ system is primarily responsible for clearing Baclofen from the body, necessitating caution in related impairment?For what acute medical events is the rapid onset of Diazepam often prioritized over Baclofen's slower oral action?How does Baclofen primarily act on motor neurons to reduce spasticity at its main site of action?
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