What inherent biological obstacle makes curing Glioblastoma extremely difficult?

Answer

These tumors infiltrate surrounding brain tissue deeply, making complete cellular removal challenging.

Glioblastoma, a form of brain cancer, presents a profound physical challenge because of its invasive nature within the central nervous system. Unlike a well-defined mass, these tumors aggressively infiltrate the surrounding, healthy brain tissue. This infiltration means that even when the main tumor mass is surgically addressed or targeted by radiation, microscopic cells or tumor strands may remain embedded deep within critical areas, rendering total elimination nearly impossible with current local treatment modalities.

What inherent biological obstacle makes curing Glioblastoma extremely difficult?
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